Avid Bioservices Inc (CDMO)

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Janus-Faced Myeloid-Derived Suppressor Cell Exosomes for the Good and the Bad in Cancer and Autoimmune Disease

Front. Immunol., 02 February 2018 | https://doi.org/10.3389/fimmu.2018.00137

Exo Composition

Exosomes are composed of a lipid bilayer, which contains transmembrane proteins. The intravesicular content is composed of proteins, coding and non-coding RNA and DNA.

The lipid envelop of Exo contains phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, prostaglandins, and lysobisphosphatidic acid and is enriched in sphingomyelin, cholesterol, GM3, and phosphatidylserine (75). The high phosphatidylserine content allows differentiating Exo from microvesicles (76) and tumor-derived Exo (TEX) lipid composition may be suited for diagnosis (77, 78). Progress in lipidomics will provide further informations.