Re: oral formulation of Ganaxolone, they failed two p3 trials in 2016 because of low oral bioavailability in the smaller dosage used then. Upcoming PPD data is IV based. It will be more potent. Ganaxolone is also going to be Captisol-enabled, just like SAGE-547 was. Even for oral formulation, they (Marinus) are planning to launch the Amaryllis study using a higher dosage.
The CDKL5 data that was reported in September last year produced very good results. They have improved their oral Ganaxolone as you can see.
Is it a sure thing? I can’t say. No one can. But I like the odds for upcoming PPD data.
Recent MRNS News
- The Gross Law Firm Reminds Marinus Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of August 5, 2024 - MRNS • PR Newswire (US) • 07/03/2024 09:45:00 AM
- Marinus Pharmaceuticals, Inc. Sued for Securities Law Violations - Contact The Gross Law Firm Before August 5, 2024 to Discuss Your Rights - MRNS • PR Newswire (US) • 06/28/2024 09:45:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/17/2024 11:01:43 AM
- Marinus Pharmaceuticals Announces Topline Results from Phase 3 RAISE Trial of IV Ganaxolone in Refractory Status Epilepticus • Business Wire • 06/17/2024 11:00:00 AM
- Form S-8 - Securities to be offered to employees in employee benefit plans • Edgar (US Regulatory) • 06/06/2024 08:55:29 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/06/2024 08:05:11 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/24/2024 10:35:01 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/17/2024 11:05:13 AM
- Marinus Pharmaceuticals Announces Key Business Updates for Tuberous Sclerosis Complex Program • Business Wire • 05/17/2024 11:00:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/08/2024 11:07:39 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/08/2024 11:05:18 AM
- Marinus Pharmaceuticals Provides Business Update and Reports First Quarter 2024 Financial Results • Business Wire • 05/08/2024 11:00:00 AM
- Marinus Pharmaceuticals to Present at the RBC Capital Markets 2024 Global Healthcare Conference • Business Wire • 05/02/2024 12:00:00 PM
- Marinus Pharmaceuticals to Provide Business Update and Report First Quarter 2024 Financial Results on May 8, 2024 • Business Wire • 05/01/2024 12:00:00 PM
- Marinus Pharmaceuticals Provides Update on the Phase 3 RAISE Trial and Reports Preliminary First Quarter 2024 Financial Results • Business Wire • 04/15/2024 11:00:00 AM
- Marinus Pharmaceuticals Announces Inducement Grants Under Nasdaq Listing Rule 5635(C)(4) • Business Wire • 04/05/2024 08:00:00 PM
- Marinus Pharmaceuticals Comments on Patent Challenge by Ovid Therapeutics Inc. and Provides Update on Marinus’ Post Grant Review • Business Wire • 03/27/2024 12:41:00 PM
- Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405] • Edgar (US Regulatory) • 03/05/2024 09:14:45 PM
- Marinus Pharmaceuticals Provides Business Update and Reports Fourth Quarter and Full Year 2023 Financial Results • Business Wire • 03/05/2024 09:01:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/22/2024 09:05:29 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/21/2024 09:06:18 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/21/2024 09:05:40 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/21/2024 09:05:24 PM
- Marinus Pharmaceuticals to Present at Upcoming Investor Conferences • Business Wire • 02/21/2024 12:00:00 PM
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Freedom Holdings Corporate Update; Announces Management Has Signed Letter of Intent • FHLD • Jul 3, 2024 9:00 AM
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BNCM and DELEX Healthcare Group Announce Strategic Merger to Drive Expansion and Growth • BNCM • Jul 2, 2024 7:19 AM
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Mass Megawatts Announces $220,500 Debt Cancellation Agreement to Improve Financing and Sales of a New Product to be Announced on July 11 • MMMW • Jun 28, 2024 7:30 AM