RespireRx Pharmaceuticals Inc (RSPI)

[apneaous]

sixteen commments below to the Medscape article from the medical community so it evoked some interest.

Dr. Jose Gros - Aymerich| Oncology 16 hours ago
OK, Cannabinoids, that are not the 'Brave New World's': 'Soma', that killed people by destroying CNS Breath control centres, and letting them choke, as those suffering 'Ondinism' who couldn't fell asleep, as they'll forget to breath and die, pretend being useful in Obstructive Sleep Apnea, perhaps mostly linked to overweight and Obesity, but: What about Central Sleep Apnea?

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Barbara Jockers| Nurse Practitioner (NP) 18 hours ago
In clinical practice,we have found dronabinol very effective--- and without side effect--- for most cases of acute anxiety/ depression. It is taken every 12 hours for the first week.and "wait time" for effect to begin is less than a week. About 50% of patients wean down on their own to taking it once a day or less, usually before bedtime. There is no noticable withdrawal, and no significant weight gain

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Dr. Richard Jackson| Psychiatry/Mental Health 17 hours ago
@Barbara Jockers

That's very interesting! Unfortunately, there isn't much in the way of human research or controlled trials of cannabinoids for treatment of psychiatric disorders.



Here's a link to an older study of cannabinoids in animal models of depression.

https://www.ncbi.nlm.nih.gov/pubmed/20332000


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Vera Cardinale| Health Business/Administration 18 hours ago
There are multiple clinical trials of a related drug, Lenabasum, made by Corbus Pharmaceuticals, for treatment of autoimmune diseases. One welcome side effect is amazing sleep.

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Dr. Richard Jackson| Psychiatry/Mental Health 19 hours ago
Some objective reduction in apneas could be potentially very useful, even if the magnitude of effect is not comparable to CPAP.

Potential applications:

1. Patients who refuse, or don't tolerate CPAP. Partially effective treatment is probably better than no treatment. And naturally sourced THC (assuming confirmation of effectiveness) can't be patented and exorbitantly priced by a big pharma company, as has been done with Marinol.

2. Patients who need treatment temporarily, when travelling without their CPAP, or away from source of electricity.

3. A partly-effective drug might enable reduction of CPAP pressure settings, making it more tolerable for some patients.

4. A drug could provide additive response to complement alternative therapies which are alone, less effective for severe apnea, such as mandibular advancement devices, or laser treatments (such as NightLase, using the Fotona Er-YAG laser).


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Dr. Franklin Stump| Psychiatry/Mental Health 19 hours ago
I’m curious if anyone on this string has problems with communication with patients about “medical marijuana use” that are practicing in states where recreational use is legal. Can anyone comment on this?

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Dr. Richard Free| General Practice 19 hours ago
An example of reverse engineering in a sense, dronabinol preceded the medical marijuana movement, but gives credence to the search for specific pure compounds of medical importance in cannabis...the access to non-specific marijuana users may advantage clinical trials by acting as a large population screening mechanism for identifying benefit...eg the seizure application...opposite to the traditional FDA process...more like the anthropological plant botanist discovery of rain forest ingenious tribe medicinal use process projected onto the indigenous native tribe of recreational/ medical US marijuana users...not judging...just sayin'...but IMO it will not be modern medical pharmacology until the relevant structures are purified, identified, and dose response determined and manufactured reliably and the efficacy is determined..until then it's herbal tea or ginseng root backyard 1800s elixir potion...and the first liar doesn't have a chance...but the OTC markets will have their day in the $un...

This may have some push on the federal justice departments since sleep apnea and truck drivers and marijuana-DOT-THC screening are now at very big policy odds...

Clinically in context...or the law of unintended clinical consequences or collateral damage, I should say...predicts sleep apnea will benefit in the short term but the cannabinoid pathway mediates the munchies side effect...munchies in sedentary truck drivers may cause more weight gain and obesity and therefore....more sleep apnea !....pass go collect 200$ and restart the cycle...


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John Herman| Clinical Nurse Specialist 19 hours ago
But wait again! Marinol is little used but FDA approved medication& if memory serves, just a hydroxyl group away. Comments anyone?

John D Herman, APRN (ret.)


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Dr. Laura Schulman| General Practice 20 hours ago
But wait...how can this be??? Cannabinoids (according to AG Sessions) are categorically illegal Schedule I substances, with no medical benefit!

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Dr. Isa Atalay| Psychiatry/Mental Health 1 day ago
is it possible to get included in also narcolepsy treatment ?

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Dr. K K Pandita| Internal Medicine 1 day ago
If long term safety of dronabinol use is established, it will prove to be a cheaper & convenient method of treatment for OSAS. It will make our lives easy.

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John Herman| Clinical Nurse Specialist 19 hours ago
@Dr. K K Pandita The problem is that according to the article, a patent is already in effect for this product, thus I am sure Big Pharma has a big stake in it as we speak!

John D Herman, APRN (ret.)


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Gary Munn| Psychologist 1 day ago
Would the consumption of Cannabis by smoking lead to the same result?

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Dr. Laura Schulman| General Practice 20 hours ago
It is NOT necessary to smoke cannabis in order to benefit from it. There are many delivery systems that do not involve fire and smoke!

And YES, herbal cannabis and its extractives can provide naturally occurring THC, which provides all of the benefits of dronabinol without the significant toxicity (including death) of the synthetic analog.


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Dr. Mahmoud Ashour| Hepatology 1 day ago
Weight reduction by sleeve operation is associated with marked improvement of sleep apnea

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Ahmed Al-Salti| Pharmacist 1 day ago
True especially I'm working with beriatric team noticed a lot of patients really did improve dramatically comparing pre surgery