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Saturday, January 27, 2018 6:24:41 AM
The Truth About Galliprant
Abstract
There are five active prostanoid metabolites of arachidonic acid (AA) that have widespread and varied physiologic functions throughout the body...
http://onlinelibrary.wiley.com/doi/10.1002/vms3.13/full
Reportedly there are some nerds who lap up this kind of stuff up like men lap up por...
Uh, I think some interested in their investment might bear to read a bit of this stuff because there is a taste of real scandal here:
Prostaglandin E2 (PGE2) is a prostanoid that serves important homeostatic functions, yet is also responsible for regulating pain and inflammation. PGE2 binds to four receptors, of which one, the EP4 receptor, is primarily responsible for the pain and inflammation associated with osteoarthritis (OA). The deleterious and pathologic actions of PGE2 are inhibited in varying degrees by steroids, aspirin and cyclo-oxygenase inhibiting NSAIDs; however, administration of these drugs causes decreased production of PGE2, thereby decreasing or eliminating the homeostatic functions of the molecule. By inhibiting just the EP4 receptor, the homeostatic function of PGE2 is better maintained.
In plain words, the angry but honest cowboy in Minnesota has been lied to by those with a vested interest in inferior drugs for treating osteoarthritis in dogs and hopefully soon in humans.
PETX was contracted by Eli Lilly to gain veterinary approval of the piprant drug Galliprant for dogs prior to Eli Lilly seeking FDA approval for human use through its own R&D.
It is not a cure. It is a maintenance drug. But it is a grand thing I tell you from our own experience as an intermediate measure before actual cures are developed.
Anybody tells you Galliprant is an NSAID or steroid is lying to you or a victim of false propaganda.
What sociopath would do such a thing?
Ask your mommy if you really don't know.
Best, Terry
Abstract
There are five active prostanoid metabolites of arachidonic acid (AA) that have widespread and varied physiologic functions throughout the body...
http://onlinelibrary.wiley.com/doi/10.1002/vms3.13/full
Reportedly there are some nerds who lap up this kind of stuff up like men lap up por...
Uh, I think some interested in their investment might bear to read a bit of this stuff because there is a taste of real scandal here:
Prostaglandin E2 (PGE2) is a prostanoid that serves important homeostatic functions, yet is also responsible for regulating pain and inflammation. PGE2 binds to four receptors, of which one, the EP4 receptor, is primarily responsible for the pain and inflammation associated with osteoarthritis (OA). The deleterious and pathologic actions of PGE2 are inhibited in varying degrees by steroids, aspirin and cyclo-oxygenase inhibiting NSAIDs; however, administration of these drugs causes decreased production of PGE2, thereby decreasing or eliminating the homeostatic functions of the molecule. By inhibiting just the EP4 receptor, the homeostatic function of PGE2 is better maintained.
In plain words, the angry but honest cowboy in Minnesota has been lied to by those with a vested interest in inferior drugs for treating osteoarthritis in dogs and hopefully soon in humans.
PETX was contracted by Eli Lilly to gain veterinary approval of the piprant drug Galliprant for dogs prior to Eli Lilly seeking FDA approval for human use through its own R&D.
It is not a cure. It is a maintenance drug. But it is a grand thing I tell you from our own experience as an intermediate measure before actual cures are developed.
Anybody tells you Galliprant is an NSAID or steroid is lying to you or a victim of false propaganda.
What sociopath would do such a thing?
Ask your mommy if you really don't know. Best, Terry
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