36 Institutional Holders 1,927,425 Total Shares Held Click on the column header links to resort ascending (?) or descending (?). Owner Name Date Shared Held Change (Shares) Change (%) Value (in 1,000s) RENAISSANCE TECHNOLOGIES LLC 09/30/2017 818,950 18,900 2.36 1,974 VANGUARD GROUP INC 09/30/2017 327,390 (75,033) (18.65) 789 AISLING CAPITAL LLC 09/30/2017 210,000 0 0.00 506 BLACKROCK INC. 09/30/2017 206,808 1,528 .74 498 CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM 09/30/2017 82,838 45,358 121.02 200 JACOBS LEVY EQUITY MANAGEMENT, INC 09/30/2017 61,721 22,421 57.05 149 CETERA INVESTMENT ADVISERS 09/30/2017 46,750 0 0.00 113 GEODE CAPITAL MANAGEMENT, LLC 09/30/2017 39,813 0 0.00 96 BANK OF NEW YORK MELLON CORP 09/30/2017 24,584 31 .13 59 MORGAN STANLEY 09/30/2017 21,694 (4,924) (18.5) 52 GOLDMAN SACHS GROUP INC 09/30/2017 15,661 15,661 New 38 NORTHERN TRUST CORP 09/30/2017 14,141 0 0.00 34 SEARLE & CO. 12/31/2017 13,325 (3,925) (22.75) 32 GROUP ONE TRADING, L.P. 09/30/2017 13,120 13,120 New 32 SUSQUEHANNA INTERNATIONAL GROUP, LLP 09/30/2017 13,096 13,096 New 32 DYNAMIC TECHNOLOGY LAB PRIVATE LTD 09/30/2017 11,937 11,937 New 29 UBS GROUP AG 09/30/2017 2,637 1,496 131.11 6