Titan Pharmaceuticals Inc (TTNP)

[KMBJN]

I ran across this paper describing pain medicines in development without the downside of existing pain meds (addiction, respiratory depression/OD):

https://www.the-scientist.com/?articles.view/articleNo/51159/title/The-Quest-for-Safer-Opioid-Drugs/

and wanted to review Titan's partnerships.

I didn't see JT pharma on the list in the above article, so I went to JT's web site.

JT Pharma appears to have an orally active kappa opioid receptor compound, HPI201:

http://www.jtpharmaceuticals.com/main/pain-pipeline

So it isn't clear why they would want to partner on an implant if they have a non-addictive, effective oral pain medicine that doesn't go into CNS or have any respiratory suppression or other central neurological side effects.

What doesn't make any sense, is they are saying the same drug can be used to prevent psychosis in schizophrenia, acting via antagonism of brain neurotensin receptors.

http://www.jtpharmaceuticals.com/main/psychosis-pipeline


It does appear they have developed HPI201 for peripheral / neuropathic pain, and got an NIH grant to help fund development:

http://webcache.googleusercontent.com/search?q=cache:WRIpuJSH91wJ:grantome.com/grant/NIH/R44-NS090629-01+&cd=1&hl=en&ct=clnk&gl=us


Here is a poster on some similar drugs they have in development - the source for some of those figures from the article Doctor Detroit posted, called JT07 and JT09:

http://www.painmed.org/2016posters/poster100.pdf

They say they did tetra-peptide modification of CR665, which appears to be Cara Pharmaceutical compound kappa opioid agonist, similar to Cara Therapeutics’s compound CR845?

CR665:
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1924123

Cara is developing CR845 for pruritus and peripheral pain:

http://www.caratherapeutics.com/pipeline-technology/kappa-opioid-receptor-agonists/

Don't know the IP status of JT Pharma / TTNP partner if they are modifying a Cara drug.

Kappa opioid or other pain meds without the existing side effects sound very promising, and I'm glad Titan is investigating them.

Whatever happened to buprenorphine implant for pain? With Braeburn a mess, it may fall by the way side.


Titan has so many potential partners, it's hard to believe that some of these applications won't be successful down the road. That and it's screaming cheap. I think it's time to double down and buy some more. Hopefully the bottom is in.