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Re: erbse24448 post# 1316

Wednesday, 10/04/2006 3:20:01 PM

Wednesday, October 04, 2006 3:20:01 PM

Post# of 51988
Thanks, Erbse. So we can add Sanofi-Aventis to the growing list of companies with AMPA upregulating programs. It looks like dipyrazoles affect NMDA activity also.

A few other AMPA programs are Boehringer Ingelheim's which has been around for a while (now with something called BIIR-777). There's also "Stargazin", which is a TARP (Transmembrane AMPA Receptor Regulatory Protein), which is apparently involved in the surface delivery and anchoring of AMPA receptors, and may also be an allosteric modulator.
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