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mcbio

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mcbio

Re: poorgradstudent post# 213558

Friday, 01/12/2018 10:08:47 PM

Friday, January 12, 2018 10:08:47 PM

Post# of 252816
GTHX -

GTHX:

Been watching it for a while. Looked into it a while ago and decided I wasn't too impressed. But now we see what that opinion is worth!

On a fundamental basis, I'm really not sure why it's ramping up. The data aren't all that clear for its lead product.

Speaking of CDK4/6 more generally, did you see this on the potential for CDK4/6 inhibitors in enzalutamide-resistant and abiraterone-resistant CRPC: http://ascopubs.org/doi/full/10.1200/PO.17.00140 ? Any thoughts on the potential of CDK4/6 inhibitors here?

Also, will what EPIX is trying to do here in targeting the N-terminal domain potentially work on this front as well?
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