Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

Administrative censoring was just a hypothetical throwaway thought. But then I started thinking (having late starts, lately. Lamentable!).

The trial was planned for 7 plus 4 weeks. 7 weeks for the radiation treatment period then 4 weeks for additional incidence observations. That is 11 weeks or 77 days total.

Placebo Kaplan Meier curve runs for 88 days, Brilacidin for 86 days. Why? The simplest explanation is (to me. Feel free to disagree) that severe OM incidents were followed until they cleared in order to get correct durations. That would mean last severe incidence in placebo cleared on day 88 and in Brilacidin on day 86.

Brilacidin has 5 censoring marks on or after day 77 which is presumably the last day to observe severe OM incidence, placebo has 3. These probably present subjects that did not have severe OM incident before day 77 and are therefore administratively censored as subjects that don't count anymore neither against incidents or durations.

Ofcourse, I can't say for sure. On the other hand, maybe they are subjects that got tired of swishing after radiation was done and just walked away from the trial. I don't know. Maybe you can come up with a more plausible explanation.