Opko Health Inc (OPK)

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Item 2.03. Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.
On December 22, 2017, a wholly-owned subsidiary of OPKO Health, Inc. (the “ Company ”), Bio-Reference Laboratories, Inc., a New Jersey corporation (“ BRLI ”), and certain of its subsidiaries entered into Amendment No. 6 to Credit Agreement (the “ Amendment ”), which amends that certain Credit Agreement (as amended, the “ Credit Agreement ”), dated as of November 5, 2015, as amended, by and among BRLI, certain of its subsidiaries from time to time party thereto, the lenders from time to time party thereto and JPMorgan Chase Bank, N.A., as administrative agent for the lenders, to permit BRLI and its subsidiaries to dividend cash to the Company in the form of intercompany loans, in an aggregate amount not to exceed $45,000,000. The other terms of the Credit Agreement remain unchanged.