Marinus Pharmaceuticals Inc (MRNS)

[jtf3]

This is a good post I saw on yahoo:

Any thoughts??

Ranger43a3 days ago
MRNS and SAGE thoughts—
Hello, everyone. I’m a science guy, so let me get right to the crux of the big issue with Ganaxolone. Will this drug be as effective as SAGE’s? Depends. For pediatric disease and epilepsy, YES. For MDD and PPD, it’s a big unknown. That’s because Ganaxolone is a modified version of Allopregnanolone (SAGE’s drug), but it’s a BIG modification. Unlike SAGE’s drug, it has no effect on the Progesterone receptor. Why is this important? Because it may very well be that this MOA is why SAGE’s drug works for MDD and PPD, and Ganaxolone MAY NOT. Conversely, the negative of SAGE’s drug is that there MAY be long term steroid (Prednisone-like) side effects due to this activity on the Progesterone receptor. This IS the receptor that Prednisone binds to that causes the steroid “euphoria” and the long-term side effects. So it’s entirely possible that SAGE’s results are nothing more than a well-known steroid-like euphoria and will eventually cause long term steroid like side effects and damage. So, in summary, Marinus’s drug, Ganaxolone, may not even work for MDD or PDD, and SAGE’s drug will work early on for MDD but cannot be used long term due to steroid-like side effects. Very interesting story. Both MAY be a bust for MDD, for different reasons. But Ganaxolone will be golden for the pediatric indications.