Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

Oh boy, a DD challenge. And a promise of surprise at the end. Goodie!

Lemme see:

SGNX must be SNGX for Soligenix otherwise things don't make sense (what??? Heart Tronics???). About that DD...

Based on a very cursory peek it seems that among some for government work (ebola vaccine collaboration, some anti-ricin plus anti radiation poisoning) Soligenix has

SGX301 in phase III for treatment of cutaneous T-cell lymphoma.
So far funded mostly by government money. Curiously, it looks like phase II results have never been published beyond press releases and one exceptionally un-informative abstract (It must have been hell to stand besides THAT POSTER). But into phase III they go...

SGX203 is for Crohn's disease. For THAT disease Clinicaltrials.gov does not recognise the drug by SGX203 or by name ( beclomethasone 17, 21-dipropionate) . Zippo. So, looks like no publications but no government money either.

I have to admit that I am already a bit surprised - cousin A. Feuerstein's way.

But hey, they HAVE published results for SGX942 or Dusquetide in oral mucositis . Let's compare with, say, Brilacidin:

Incidience rate for severe OM
Dusquetide IV: 69.4 %
Brilacidin Oral: 42.9 %

Hazard rate vs placebo:
Dusquetide IV: 0.942 (meaning about there with placebo)
Brilacidin Oral: 0.714 (no lower HR on record for OM in head and neck c)

Improvement in duration of severe OM:
Dusquetide IV: based on 36 treated vs 38 on placebo, reduction in median duration is 50 % on the nose. The tougher measure, reduction in mean duration is, curiously, not reported.
Brilacidin Oral. So far, only interim data from phase II. Based on 2 subjects treated vs 7 on placebo, reduction on mean (reporting for median would have been silly) is unimpressive 25 %. But, mean of 2 samples, you must be kidding me.

And the bonus: ulcerative oral mucositis.
hazard rate for incidence
dusquetide vs placebo: 1.05 i.e. you would be better off with placebo.
Brilacidin vs placebo. Not yet known but only way it could be worse than dusquetide is if it will put subjects to coffin faster than placebo.

You were right, I am profoundly surprised that Soligenix has MC of 15 million. Must be because of that vaccine and anti-radiation work.