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Provectus News

Provectus Biopharmaceuticals Receives Third Cancer Combination Therapy Patent from the United States Patent and Trademark Office

- Protection expands coverage for combinations of intralesional PV-10 with checkpoint inhibitors for multiple solid tumor cancers -

Thursday December 14, 2017

KNOXVILLE, TN, /Globe Newswire/ -- Provectus Biopharmaceuticals, Inc. (OTCQB: $PVCT, www.provectusbio.com), ("Provectus" or the "Company"), a clinical-stage biotechnology company developing a novel therapeutic platform based on halogenated xanthenes for the treatment of multiple diseases, including cancer and inflammatory dermatoses, today announced the United States Patent and Trademark Office (the "USPTO") has granted U.S. patent ("USP") 9,839,688 for the combination of intralesional ("IL") PV-10 with systemic immunomodulatory therapy, including anti-PD-1 and anti-PD-L1 agents, for the treatment of solid tumor cancers. This new patent is a continuation of USP 9,107,887, Provectus' first cancer combination therapy patent granted by the USPTO in 2015, and is related to USP 9,808,524, the Company's second cancer combination therapy patent granted by the USPTO in November 2017. Pfizer, Inc. is a co-assignee on all three patents.

Dominic Rodrigues, Chairman of the Company's Board of Directors, said, "This third patent represents our further efforts to increase the potential commercial value of Provectus' clinical development program in cancer combination therapy. Notably, the new addition to this part of the Company's patent estate includes coverage for multiple solid tumor cancers that are already in our research and development pipeline."

Mr. Rodrigues added, "Over time, Provectus and our research and clinical collaborators have jointly or independently shown, on a preclinical or clinical basis, the combination of PV-10 and another class of agent or therapy, including checkpoint inhibition, chemotherapy, and radiation, in multiple cancer indications, including hepatocellular carcinoma, melanoma and pancreatic cancer. These data have been presented at conferences of the Society for Immunotherapy of Cancer and Society for Melanoma Research, and published in the Journal of Surgical Oncology, and Melanoma Research."

The complete press release is available at http://www.provectusbio.com/news/press-releases/provectus-pr-20171214-1 on the Provectus website.