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Thursday, 12/14/2017 7:34:38 AM

Thursday, December 14, 2017 7:34:38 AM

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Great news out!
https://finance.yahoo.com/news/axsome-therapeutics-collaborates-world-leading-120000998.html
Results of preclinical studies conducted at Duke University demonstrated that the dextromethorphan component of AXS-05 significantly reduced nicotine self-administration in nicotine-dependent rats in a dose-dependent manner (p<0.0005 versus control) [1]. Results of pharmacokinetic clinical trials conducted by Axsome have demonstrated that, in human subjects, AXS-05 results in a significant increase in dextromethorphan plasma concentrations (p<0.0001 versus administration of dextromethorphan as a single agent). Furthermore, bupropion, a component of AXS-05, has been found to be effective for smoking cessation in clinical trials. The preclinical and clinical efficacy of the individual components of AXS-05 combined with their positive pharmacokinetic interaction supports the potential for AXS-05 to be effective in the treatment of tobacco dependence in humans.
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