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Wednesday, December 13, 2017 10:52:43 AM
The problem is that Dusquetide reduced mean duration by 50% from 18 to 9 days
That’s not the problem for Dusquetide. Here is the problem for Dusquetide....
This exploratory study achieved all objectives, including identifying a best dose of 1.5 mg/kg. The study enrolled patients across three SGX942 dose groups (i.e., 1.5, 3.0, and 6.0 mg/kg administered IV over 4 minutes) and a placebo group and evaluated patients undergoing chemoradiation therapy for head and neck cancer. In the 1.5 mg/kg treatment group, the median duration of severe oral mucositis was decreased by 50%, from 18 days to 9 days (p=0.099), meeting the prospectively defined statistical threshold of p<0.1 in the study protocol. Further, patients receiving the most aggressive chemoradiation in this dose group had even more striking reductions in their median duration of severe oral mucositis of 67%, from 30 days to 10 days (p=0.040).
They made their P value target by the hair on their chinney chin chin, and more drug work worse than less drug? How about zero drug, would that be better? That’s the opposite of what you want to see as far as I understand CT results.
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