Ayala Pharmaceuticals Inc (ADXS)

[jondoeuk]

Kite (http://ir.kitepharma.com/releasedetail.cfm?ReleaseID=1037572), Adaptimmune, Ziopharm and others are using TCRs to target a range of solid tumours. If we take $ZIOP then they have signed a CRADA with the NCI for the development of adoptive cell transfer based immunotherapies using the Sleeping Beauty transposon/transposase system to produce genetically modified T-cells that express TCRs to target neoantigens. If all goes well a second trial will test that with added membrane-bound interleukin-15 under the control of Veledimex, an oral small-molecule activator ligand. This could do away with the need for lymphodepleting chemo.

Not forgetting $IOVA using TILs