Monday, December 11, 2017 1:03:53 PM
thanks for the post - insightful - and a fair assessment
signal is there, and likely powered enough, esp in context of Huge Unmet Need, and B-OM showing Prevention not Amelioration
see this:
Some common misperceptions about p-values
"For a certain Phase II clinical trial, where the safety and efficacy of a new treatment is still being explored, one can argue for a more liberal alpha to give the treatment a higher level of the benefit of doubt, especially when the disease or condition have only a few, if any, effective treatment options. If it should pass, it would be weeded out in a Phase III trial with a more stringent significance level."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245357/
and another read:
Common misconceptions about data analysis and statistics
http://onlinelibrary.wiley.com/doi/10.1111/bph.12884/full
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