Sunday, December 10, 2017 9:43:25 PM
I mean the company now knows what dosage to use going forward which is a big plus, but they still need to come up with optimal intervals to give the drug. If they had to revise the trial midstream due to 40 ug side effects, which apparently they did, it would have been really beneficial to bump the 20 ug patients from 12 to 24 weeks while they already had them on the drug. Looking at the CU patient results, the averages of the 35 or so patients on the 20 ug in the 2b study seem to match up well and if that pattern held (which is certainly suggested from the data presented in July regarding the 17 week data point and comments made by Wilke earlier) then a 24 week study could have been blockbuster for us. Instead its caused a major delay.
Can't wait to see further results as the 10q stated. Would really like to see if any larger response in APOE4 patients. Wonder if this could be a reason for Dr. Perry signing on?
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