Pluristem Therapeutics Inc (PSTI)

[zzaatt]

Spideyboy, I admire your incredible patience and generosity
in this post (let's see if it can penetrate anyone's consciousness).

Couple of minor points:

With regards Yaky, I can't say I'm as impressed.
2. As far as I can see, no it does not appear that their bonuses were justified as yet.

Too early to tell!
If we're at 15 next year, then we can say retroactively
that their bonuses were justified. Also, it's a simple fact
that their remuneration is not out of line with
other similar companies.


Usually, any reference to mouse models is met with
mirth (you know, the "LMFAO" kind) and sneering on message boards.
Here's one (of many) articles that powerfully refute that attitude:

Humanized mouse models of clinical disease
From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280554/
Immunodeficient mice engrafted with functional human cells and tissues,
i.e., “humanized mice”, have become increasingly important as small pre-clinical animal models for the study of human diseases.
Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rgnull) in the early 2000’s,
investigators have been able to engraft murine recipients with
human hematopoietic stem cells that develop into functional human immune systems.
These mice can also be engrafted with human tissues such as islets, liver, skin, and most solid and hematologic cancers.
Humanized mice are permitting significant progress in studies of human infectious disease,
cancer, regenerative medicine, graft versus host disease, allergies, and immunity.
Ultimately, use of humanized mice may lead to the implementation of truly “personalized” medicine in the clinic.

Totally agree with your statement:

The science really seems astounding. The last bit of additional data that PSTI came out with last week with additional CLI murine study was quite amazing

Yes, it's true, clinical trials are still necessary (!!!!!), but isn't it nice
to have corroboration of assumptions about MOA, sort of like
seeing a road sign on the way to your destination.