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Monday, 11/20/2017 3:29:08 PM

Monday, November 20, 2017 3:29:08 PM

Post# of 21523
bryostatin supply update from October

Good news from the Wender group who we have partnered with. Sounds like they've just synthetically produced enough for further alzheimer's trials of up to 2000 patients.

https://www.chemistryworld.com/news/route-to-fiendishly-complex-marine-molecule-cut-in-half/3008128.article

‘What makes Wender’s bryostatin 1 synthesis stand out is the fact that it is largely stereo-controlled and efficient, with no step proceeding in a yield that is less than 75%,’ Hale says. ‘The final 2g quantity of natural product that they have prepared is simply breath-taking and can now lead to this molecule being clinically evaluated as a potentially revolutionary anti-Alzheimer’s drug in close to 2000 patients.’

Additional info
http://blogs.discovermagazine.com/d-brief/2017/10/12/bryostatin-1-cancer-supply/#.WhM8TVWnGM9

https://www.ncbi.nlm.nih.gov/pubmed/29026042
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