Momenta Pharmaceuticals, Inc. (MNTA)

[Boing x 2]

New pre patent approval,

https://worldwide.espacenet.com/publicationDetails/claims?CC=ES&NR=2605677T3&KC=T3&FT=D&ND=3&date=20170315&DB=&locale=en_EP

This one is hard to comprehend.

https://worldwide.espacenet.com/publicationDetails/description?CC=ES&NR=2605677T3&KC=T3&FT=D&ND=3&date=20170315&DB=&locale=en_EP

If they can impact all these drugs it will be beyond comprehension.


[000125] In another embodiment, a glycoprotein is produced having reduced levels of Gal-alpha-Gal glycan structures relative to a glycoprotein in the prior art having the same or highly similar polypeptide sequence (e.g., at least 90%, 91 %, 92%, 93%, 94%, 95%, 96%o, 97%o, 98%o, 99%o identical polypeptide sequence). The method includes culturing a CHO host cell described herein that has been genetically engineered to produce reduced levels of Chinese hamster or CHO cell Ggtal relative to the parent cell (e.g., a Ggtal knock-out or knock-down CHO cell described herein), where the host cell contains a transgene encoding a therapeutic glycoprotein, and purifying the therapeutic glycoprotein from the resulting cultured cells. Such glycoproteins thus produced can provide improved versions of marketed therapeutic glycoproteins.

TABLE 5

Protein Product Reference Drug

interferon gamma- lb Actimmune<®>

alteplase; tissue plasminogen activator Activase<®>/Cathflo<®>

Recombinant antihemophilic factor Advate

human albumin Albutein<®>

laronidase Aldurazyme<®>

interferon alfa-N3, human leukocyte derived Alferon N<®>

human antihemophilic factor Alphanate<®>

virus-filtered human coagulation factor IX AlphaNine<®> SD

Alefacept; recombinant, dimeric fusion protein LFA3-Ig Amevive<®>TABLE 5

Protein Product Reference Drug bivalirudin Angiomax darbepoetin alfa ™

Aranesp bevacizumab Avastm • ™ interferon beta- la; recombinant Avonex<®> coagulation factor IX BeneFix™

Interferon beta- lb Betaseron<®>

Tositumomab Bexxar<®> antihemophilic factor Bioclate™ human growth hormone BioTropin™ botulinum toxin type A Botox<®> alemtuzumab Campath<®> acritumomab; technetium-99 labeled CEA-Scan<®> alglucerase; modified form of beta-glucocerebrosidase Ceredase<®> imiglucerase Cerezyme<®> crotalidae polyvalent immune Fab, ovine CroFab™ digoxin immune Fab, ovine DigiFab™ rasburicase Elitek<®> etanercept Enbrel<®> epoietin alfa Epogen cetuximab Erbitux™ algasidase beta Fabrazyme<®> urofollitropin Fertinex™ follitropin beta Follistim™ teriparatide Forteo<®> human somatropin GenoTropin<®> glucagon GlucaGen<®> follitropin alfa Gonal-F<®> antihemophilic factor Helixate<®>

Antihemophilic Factor; Factor XIII Hemoffl<®> insulin Humalog<®> antihemophilic factor/von WiUebrand factor complex Humate-P<®> somatotropin Humatrope<®> adalimumab HUMIRA™ human insulin Humulin<®> recombinant human hyaluronidase Hylenex™ interferon alfacon- 1 Infergen<®>TABLE 5

Protein Product Reference Drug

Eptifibatide Integrum

alpha- interferon Intron A<®>

palifermin Kepivance

anakinra Kmeret

antihemophilic factor Kogenate<®>FS

insulin glargine Lantus<®>

granulocyte macrophage colony-stimulating factor Leukine <®>/Leukine<®> Liquid lutropin alfa, for injection Luveris

OspA lipoprotein LYMErix™

ranibizumab Lucentis<®>

gemtuzumab ozogamicin Mylotarg™

galsulfase Naglazyme™

nesiritide Natrecor<®>

pegfilgrastim Neulasta™

oprelvekin Neumega<®>

filgrastim Neupogen<®>

fanolesomab NeutroSpec™ (formerly LeuTech<®>) somatropin [rDNA] Norditropin<®>/Norditropin Nordiflex<®> insulin; zinc suspension; Novolin L<®>

insulin; isophane suspension Novolin N<®>

insulin, regular; Novolin R<®>

insulin Novolin<®>

coagulation factor Vila Novo Seven<®>

somatropin Nutropin<®>

immunoglobulin intravenous Octagam<®>

PEG-L-asparaginase Oncaspar<®>

abatacept, fully human soluable fusion protein Orencia™

muromomab-CD3 Orthoclone OKT3<®>

human chorionic gonadotropin Ovidrel<®>

peginterferon alfa-2a Pegasys

pegylated version of interferon alfa-2b PEG-Intron™

Abarelix; gonadotropin-releasing hormone antagonist Plenaxis™

epoietin alfa Procrit<®>

aldesleukin Proleukin, IL-2<®>

somatrem Protropin<®>

dornase alfa Pulmozyme<®>TABLE 5

Protein Product Reference Drug

Efalizumab; selective, reversible T-cell blocker aptiva

combination of ribavirin and alpha interferon Rebetron

Interferon beta 1 a Rebif<®>

antihemophilic factor Recombinate<®> rAHF/ntihemophilic factor ReFacto<®> lepirudin Refludan<®> infliximab Remicade<®> abciximab ReoPro™ reteplase Retavase™ rituximab Rituxan™ interferon alfa-2a Roferon-A<®> somatropin Saizen<®>

synthetic porcine secretin SecreFlo™ basiliximab Simulect<®> eculizumab Soliris<®>

pegvisomant Somavert<®>

Palivizumab; recombinantly produced, humanized mAb Synagis™ thyrotropin alfa Thyrogen<®> tenecteplase TNKase™ natalizumab Tysabri<®> human immune globulin intravenous Venoglobulin- S<®> interferon alfa-nl, lymphoblastoid Wellferon<®> drotrecogin alfa Xigris™

Omalizumab Xolair<®>

daclizumab Zenapax<®> ibritumomab tiuxetan Zevalin™

Somatotropin Zorbtive™ (Serostim<®>)

[000126] Other features and advantages of the invention will be apparent from the following detailed description, and from the claims.

[000127] This invention is further illustrated by the following examples that should not be construed as limiting. The contents of all references, patents and published patent applications cited throughout this application are incorporated herein by reference.

Boing X 2