Biotech Values

[poorgradstudent]

MYOK:

I have a rule never to be excited by new hires. I don't think they're a reliable signal of program success or failure.

For example, Dr. Semigran was involved in the RELAX study which used sildenafil to target PDE-5 in the heart for HFpEF. Only problem? Many researchers have shown PDE-5 protein is not really expressed in the heart, and the trial was predictably a giant flop. See here.

Also, Dr. Semigran is involved in another garbage HFpEF trial, INDIE-HFpEF delivering nitrite. Guess what the biological "rationale" is? The same as the RELAX trial. Scientific process much?

I think it's easier to work off the clinical data rather than pushing reputations.