Avid Bioservices Inc (CDMO)

[hutschi]

Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases

Three reasons why exosomes show tremendous potential in the field of nanomedicines are (1) exosomes can cross the blood-brain barrier to deliver therapeutic drugs or antioxidants, (2) exosome membranes are rich in sphingomyelin, cholesterol and glycerophospholipids with long, saturated fatty acyl chains and phosphatidylserine, which increases their stability and potentially favors their uptake, thus making them effective drug delivery vehicles, and (3) exosomes derived from the same species typically should have only minimal immunogenicity, thus reducing the potential risk of an immune response. However, the challenge here is to develop target-specific exosomes.

https://academic.oup.com/toxsci/article/158/1/3/3827743