OncoSec Medical Inc (ONCSQ)

[hschlauch]

Titan, there are a few things I want to quickly point out in regards to Oncosec's first multigene construct:

1. They are essentially creating a plug-and-play platform that would allow for the creation of personalized cancer vaccines. They have demonstrated in this first multigene construct that they can successfully express three encoded genes on one plasmid. One of these genes can be an encoded antigen that gets expressed with IL-12 and an flt3 ligand. The encoded antigen is part of a fusion protein that, together with flt3 ligand, facilitate the maturation of dendritic cells. These mature dendritic cells then present the antigen to T cells for activation.

2. Flt3 ligands lead to the proliferation of dendritic cells - this is a major deal. In theory, this would improve antigen presentation, therefore improving immune responses. The presented data show that CD8-positive T cells targeting the encoded antigens do in fact proliferate significantly in vivo.

3. They are using the new GENESIS EP device.

4. The genes are all P2A-linked.

More to come later...