Avid Bioservices Inc (CDMO)

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Context-dependent compensation among phosphatidylserine-recognition receptors

Published online:07 November 2017

Introduction

Cell death is a crucial part of life. Each day, billions of cells in the human body undergo apoptotic cell death and must be cleared1,2,3. In many tissues, dying cells are cleared by phagocytes that engulf and digest the apoptotic corpse3,4,5. Impediments to apoptotic cell clearance can lead to chronic inflammation and autoimmunity6,7,8,9. Apoptotic cell clearance is stimulated upon apoptotic cell exposure of the ‘eat-me’ signal phosphatidylserine (PtdSer) and its subsequent recognition by PtdSer receptors on phagocytes10,11,12. Phagocytes express a multitude of PtdSer receptors, yet, despite extensive research on apoptotic cell recognition and clearance, the relative importance of PtdSer receptors in a given phagocyte or tissue context is unclear4,13.......

http://www.nature.com/articles/s41598-017-15191-1