Viking Therapeutics Inc (VKTX)

[hptaxis]

Further, hypogonadism post cessation will lead to a loss of positive [anabolic] effects. In addition the adverse change in SHBG [metabolic syndrome]. 2 mg will probably have more of an adverse effect. This drug will never be approved for any number of reasons. [Note: BMD changes are not typically seen in 3 months. If they are, red flag!]




(A) The effects of LGD-4033 selective androgen receptor modulator on serum total testosterone levels. Change from baseline in serum total testosterone levels are shown. The data are mean ± standard error of the mean (SEM), n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(B) Change in the free testosterone levels from baseline. Change from baseline in serum free testosterone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(C) Change in sex hormone–binding globulin levels from baseline. Change from baseline in serum sex hormone–binding globulin levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(D) Change in luteinizing hormone (U/L) levels from baseline. Change from baseline in serum luteinizing hormone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(E) Change in follicle-stimulating hormone (U/L) levels from baseline. Change from baseline in serum follicle-stimulating hormone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(F) Change in prostate-specific antigen (ng/mL) levels from baseline. Change from baseline in prostate-specific antigen levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.