Innovation Pharmaceuticals Inc (IPIX)

[DaubersUP]

I'm looking at the data AGAIN. I think yours and others confusion comes with the fact this was for MILD to MODERATE using the IGA scale.
0-clear
1-almost clear
2-mild
3-moderate


Placebo rates for this population are much higher. MUCH MUCH MUCH higher.


When you start comparing other drugs, they tend to MODERATE to SEVERE and also use the PASI scale

For IGA that is
4-severe
5-very severe.


So one can conclude that the trial design IPIX chose for the phase 2a was extremely stringent. I think Dr B even made mention in a presentation just how difficult the criteria was. But they had full confidence they could leave that 2a trial with something to show to move to a POWERED phase 2b trial using the same and much weaker criteria that others have used.

We can agree that the data want overwhelming in any way for the phase 2a. However, the interesting part is the response in a dose dependent fashion and the fact that the more moderate the psoriasis the better the response.

So that leads me to HOPE, that bumping the dose from 200 to 300 and 400 in this next trial and testing a population that starts as a 3 and 4 and 5 could have exceptional results.

I think the data in phase 2a for ALL patients with IGA 3 TAKING THE 200 dose achieved the 2 pt or more reduction like 55%

Now to me...that is significant.