Titan Pharmaceuticals Inc (TTNP)

[Doctor Detroit]

A lot of new information in the poster....


"Therapeutic substitution of L-T3 for L-T4 has been evaluated in hypothyroid subjects in a blinded crossover study with a multiple daily dosing scheme, and comparison of L-T3 and L-T4 doses that produce equivalent steady-state thyroidstimulating hormone (TSH) levels additionally resulted in L-T3-mediated weight loss and positive changes to lipid profiles without appreciable side-effects (1,2). A sustained-release L-T3 formulation could avoid issues of noncompliance to multiple daily dosing regimens."


So, T3 has already been studied as a substitute for T4 in a separate study (not run by Titan), and resulted in weight loss and positive changes to cholesterol levels.


"In beagle dogs, which closely match implant-derived serum levels seen in humans, the initial peak release from 3 implants (Cmax = 221 ng/dL,Tmax = 6 hours) was about 1.7-times that of the Css (128 ng/dL), which was sustained from 12 hours post-implantation through Month 8. Residual content analysis of implants removed on post-implantation Day 217 indicated that an average of 21% of the original L-T3 content was released. Assuming similar release characteristics in humans, 1 implant (227 mg L-T3/implant, 3 x 26 mm) will release the equivalent of ~25 mcg oral L-T3/day for >3 years following a single treatment."

Am I reading this right? A THREE YEAR implant???

"Serum samples taken before and after implant removal from dogs on Day 217 were also assayed for LDL, HDL and triglycerides levels. LDL levels went up from 4 mg/dL to 7 mg/dL, peaking at 48 hours post-implant removal. Triglycerides levels also rose from 31 mg/dL to 54 mg/dL, peaking at 12 hours post-implant removal (inset), and HDL levels dropped from 131 mg/dL to 118 mg/dL, with a trough at 24 hours post-removal (inset)."

So following removal of the Titan's implant, HDL (the “good cholesterol” decreased) and LDL and triglycerides (the “bad cholesterol”) increased, consistent with the findings in other studies.