Vascular Biogenics Ltd (VBLT): Trial will be stopped if mOS improved by...

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Re: staccani post# 1383

Saturday, 09/30/2017 3:36:03 PM

Saturday, September 30, 2017 3:36:03 PM

Trial will be stopped if mOS improved by 50%+. Optune's trial was stopped with less significant improvement in mOS:

In the per-protocol population, patients treated with TTFields plus temozolomide demonstrated a statistically significant increase in OS, a powered secondary endpoint, compared to temozolomide alone (median OS 20.5 months versus 15.6 months, hazard ratio=0.64, p=0.0042). In the intent-to-treat population, the median OS was 19.6 months versus 16.6 months, respectively, hazard ratio=0.74 (p=0.0329).

http://www.businesswire.com/news/home/20151215005370/en/Journal-American-Medical-Association-JAMA-Publishes-Pivotal

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