Amarantus Bioscience Holdings Inc (AMBS)

[JPetroInc]

MANF discovered in 2003 is still in rat testing phases - what's wrong with this picture?

surely some big BioPharma wants to invest in this and make $-Bil's. - no?

I guess after almost 15 years, genome decoding and stem cell explosions - the intrigue and love is long gone for MANF...

sad but true...

https://www.nature.com/articles/s41467-017-00750-x

The hypothalamus has a vital role in controlling food intake and energy homeostasis; its activity is modulated by neuropeptides and endocrine factors. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic factor that is also localized in the endoplasmic reticulum (ER) in neurons. Here we show that MANF is highly enriched in distinct nuclei of the mouse hypothalamus, and that MANF expression in the hypothalamus is upregulated in response to fasting. Increasing or decreasing hypothalamic MANF protein levels causes hyperphagia or hypophagia, respectively. Moreover, MANF triggers hypothalamic insulin resistance by enhancing the ER localization and activity of PIP4k2b, a kinase known to regulate insulin signaling. Our findings indicate that MANF influences food intake and body weight by modulating hypothalamic insulin signaling.