Avid Bioservices Inc (CDMO)

[hutschi]

The Multi-Purpose Tool of Tumor Immunotherapy: Gene-Engineered T Cells

http://www.jcancer.org/v08p1690.htm

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Combination therapy for cancer

In the course of cancer treatment, the ACT can be existed alone, or acted as a part of the combination therapy. For example, a human IgG1 T-cell receptor mimic monoclonal antibody directed to a peptide (RMFPNAPYL) of WT1 in HLA-A*02 dependent was therapeutically effective, alone and in combination with tyrosine kinase inhibitors (TKIs), against a leukemia with the most common, pan-TKI, gatekeeper resistance mutation, T315I [111]. Whether WT1-targeted TCR and the mimic monoclonal antibody combination therapy will produce a similar effect? If so, this strategy will become an option for TKIs resistance in cancer therapy. As noted above, tumor vaccines have a unique advantage in inducing TAA-specific TCR. The tumor radiotherapy can produce a similar effect. The vaccine-similar effect was contributed non-redundant immune mechanisms in cancer by a combination of radiotherapy and dual checkpoint blockade [121]. Maybe it is a very imaginative treatment combination that ACT is combined with radiation therapy.
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