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Saturday, 09/02/2017 9:24:28 AM

Saturday, September 02, 2017 9:24:28 AM

Post# of 403047
Look at page 12 of the following PowerPoint presentation

https://static1.squarespace.com/static/5715352e20c647639137f992/t/583f7f14bebafbe20767391b/1480556310644/Prurisol-Presentation-for-Med-Derm-RD-Workshop_19Sep2016-u.pdf

Look at the graph on the right side of the page

For the Prurisol 200 mg (Per Protocol Population)

65% of this cohort started at IGA 3 (moderate psoriasis)

By 6 weeks into the trial those patients taking 100 mg of Prurisol twice per day per protocol those patients originally classified as IGA 3 (moderate) dropped from 65% to 30% that is a 35% drop in just 6 weeks. During the same 6 week period those patients classified as IGA 2 (mild psoriasis) increased from 35% to 50% a 15% increase (apparently 15% of the population moved from IGA 3 (moderate) to IGA 2 (mild)). During the same 6 week period those classified as IGA 1 (almost clear) increased from 0% to 20%.

By just 8 weeks into the trial those classified as either IGA 1 (almost clear) or IGA 0 (clear) increased from zero percent at the start of the trial to 40% after just 8 weeks from the start of the trial for those taking 100 mg of Prurisol twice per day per protocol.

By just 12 weeks into the trial those classified as either IGA 1 (almost clear) or IGA 0 (clear) increased from zero percent at the start of the trial to 55% after just 12 weeks from the start of the trial for those taking 100 mg of Prurisol every 12 hours per protocol.

The current trial doses are 1.5 and 2 times the 100 mg of Prurisol twice per day per protocol form the previous trial.

Good luck and GOD bless,

George
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