Ayala Pharmaceuticals Inc (ADXS)

[friendofthedevil]

Well, that's H&N. A different beast. Perhaps some prostate tumor regression could happen after a time.

My main point was that in prostate cancer, the tumor doesn't have to shrink before survival is positively affected. Keytruda is in ten trials for prostate cancer right now. Only one other trial pairs it with an antigen (vaccine): Biological: pTVG-HP Plasmid DNA Vaccine. The results of this weak vaccine by itself have not even shown stable disease - as far as I can see/find.

So, stable disease in the early stages of a Ph1/2 vaccine dosing trial ain't bad.

The treatment of CRPC is to use the next level of antiandrogen therapy, if it hasn't been used before, and then possibly some radiation. When Xtandi or Zytiga are finished, it will be time for immunotherapy. It is a long ways off but Ketruda + LmPSA has as good a shot as any.