Avid Bioservices Inc (CDMO)

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Kymriah[CAR-T] "...may cause side effects that are fatal or life-threatening, such as Cytokine Release Syndrome (CRS) or Neurological Toxicities. Patients with CRS may experience symptoms including high fever, difficulty breathing, chills/shaking chills, severe nausea, vomiting and diarrhea, severe muscle or joint pain, very low blood pressure or dizziness/lightheadedness. Patients may be admitted to the hospital for CRS and treated with other medications.”

“Novartis receives first ever FDA approval for a CAR-T cell therapy, Kymriah™ (tisagenlecleucel, CTL019)...”

Peregrine’s anti-PS mAb, when used in combination with CAR-T, supports efficacy, and provides much needed safety.


The CAR-T Anti-PS combination study was accomplished at the Memorial Sloan Kettering Cancer Center.

POSTER:

http://www.peregrineinc.com/images/stories/pdfs/aacr2017hirschhorn.pdf

IMO

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