Pluristem Therapeutics Inc (PSTI)

[Scott999]

Does anyone know the level of radiation Pluristem used in their ARS trial. I have been trying to find some sort of comparison, as this was taken from the press release in 2012 from Cleveland Biolabs regarding their study.

"Animals in the study received a 70% lethal dose of total body irradiation (TBI) followed by a single injection of a range of doses of CBLB502 or a placebo, in each case, 25 hours after irradiation. In addition to determination of 60-day survival, the study measured multiple pharmacodynamic parameters which the Company believes are essential for animal-to-human dose conversion."

A 70% lethal dose?

Entolimod use LD 50-70/40

Filgratim used these rates.

Animals were exposed to total body irradiation, antero-posterior exposure, total midline tissue dose of 7.5 Gray, (target lethal dose 50/60) delivered at 0.80 Gray minute-1, using linear accelerator-derived 6 Megavolt photons.

Pluristem's mouse study used 7.7 GY

Don't know the difference, but would love to know the exposure level in our nhp trial. Without the same radiation exposure, or knowing how quickly it was delivered, the comparison of results become skewed. Maybe somebody who understands these levels could assist. Or if anyone could find more info that would be great.