Avid Bioservices Inc (CDMO)

[hutschi]

Bayer : Patent Issued for Gla Domains as Targeting Agents (USPTO 9694048)

BACKGROUND
1. Field

This disclosure relates to the targeting of phosphatidylserine (PtdS) on cell membranes using Gla domain peptides and polypeptides. The use of these peptides and polypeptides as therapeutic agents is disclosed.

2. Related Art

Phosphatidlyserine (PtdS) is a negatively charged phospholipid component usually localized to the inner-leaflet (the cytoplasmic side) of the cell membrane. However, PtdS can be transported by scramblase (a member of the flippase family) from the inner-leaflet to the outer-leaflet and exposed on the cell surface. With very few exceptions, this active externalization of PtdS is a response to cellular damage (van den Eijnde et al., 2001; Erwig and Henson, 2008). For example, tissue injury signals platelets, leukocytes, and endothelial cells to rapidly and reversibly redistribute PtdS which leads to the promotion of coagulation and complement activation on cell surfaces.......

https://www.google.com/patents/US9694048

http://www.4-traders.com/BAYER-436063/news/Bayer-Patent-Issued-for-Gla-Domains-as-Targeting-Agents-USPTO-9694048-24749589/