Innovation Pharmaceuticals Inc (IPIX)

[Scottwny]

Otezla pre-clinical mouse study - I believe this is it:

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00559.x/full

Quotes from Discussion Section:

"Notably, four of seven (57%) grafts from the apremilast-treated mice underwent a partial or complete recovery of histological features; whereas, three of seven grafts from cyclosporine-treated group displayed a histological recovery."

"Together, these data suggest that the human skin xenotransplant SCID mouse model may serve as a tool for investigating potential agents directed against the pathophysiological mechanisms of psoriasis. The anti-inflammatory activity of apremilast, as demonstrated in vitro and in a preclinical psoriasis model, has translated into clinical efficacy in this disease."

IPIX Press Release Quote (12/19/2016):

In laboratory studies, Prurisol was found to be effective against psoriasis in animal models, both in induced psoriasis and in a xenograft model using human psoriatic tissue. In these models, Prurisol eliminated virtually all signs of psoriasis.