Innovation Pharmaceuticals Inc (IPIX)

[cabel]

I think you miss his point!

!) We know we had at least a one point reduction in the degree of psoriasis in 55% of the patients in the 27 patients of the 200mg arm.

2) We know that the drug is dose dependant, the higher the dose the more effective it is.

3) We know what we know from the pre-clinical mouse studies which were spectacular.

4) We know it is very unlikely to have ASE at the higher dosing levels of 300-400mg

5) We know that the drug starts having a positive affect on psoriasis at week 2 with 200mg

6) We know it is easier to get better results with Mod/Sev than Mild/Mod.

7) We know our MODERATE patients responded better than our MILD.

8) We know that an IGA score of 0 or 1 is equivalent to PASI90.

9) We know that the patient satisfaction in the 200mg was high.

10) We know Dr Menon has not failed one trial in at least 5 years.

11) We know Leo has opened many new sites and that he has access to patients results (without knowing what arm they are in)

And against all that the only thing that you have to say is,...

Yes but the patient pool was small.

I agree with that,.. and that is why we now dosing are 189 patients in just two dose levels in current Phase 2b. Almost everyone here knows that. But at the same time we know other things about the Phase 2b,.. many of which point to a probable positive outcome.

We tend to look at other things as well as the fact that we had a PoC type trial in Phase 2a (so as to find the right dose),..whereas you look at one thing,... which sets you apart as being very frustrating to discuus anything with.

The ability to see both sides of an argument is the sign of a mature adult,.. try it some time.

If we did a 200 patient trial on B-UP with 200mg dose with foam,.. I would see lots of positives that would indicate it would work and I would put it all together and feel very good about the possiblities.

Plus I would see that the first trial was with just 15 patients and it was small. But that would not take away all the positive things I would see about the samll trial.

We are not saying Phase 2b Prurisol is a 100% lock,... we are saying things are pointing in that direction.

You are saying there is no way to know.

You see one thing and one thing only!

What would you do if you ever served on a Jury and there was ONLY CIRCUMSTANTIAL evidence...?