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Re: DewDiligence post# 976

Monday, 09/11/2006 11:16:27 PM

Monday, September 11, 2006 11:16:27 PM

Post# of 12660
You have failed to respond to the question.

You have argued in many posts that the p value needs to be allocated between TTP (a surrogate test) and survival (ultimate test).

Others (Clark & Ocyan) have argued that there is no need for allocation between a surrogate and the ultimate test.

So I ask you again for an example in which the FDA allocated p value between a surrogate test and the ultimate test, like a trial in which p value threshold for survival is reduced because there was an earlier surrogate test (like TTP).

Should you fail to provide an example, I can't help wonder if your view on this topic is just another example of hot air.
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