Avid Bioservices Inc (CDMO)

[Protector]

biopharm, not sure if I see anything on Dr Wolchok? Have you provided the correct link.

BTW: Tizona' approach was OK before it was know what Fx-Gamma binding (by Bavituximab) does. It triggers cytokine IL-12 secretion (Immune system stimulation) by the MDSCs and suppresses IL-10 secretion (Immune system suppressor).

So making synthetic IL-12 cytokines is USELESS. We also know today that you need to hit ALL PS-Receptor type AT ONCE (on MDSC's, M2 Macrophages, TIM's, etc about 11 of them). One must condition the COMPLETE TUMOUR environment in SYMPHONY. That is why those TIM strategies don't have the expected magnitude of effect.

BTW: TIZONA: POOOOOOOOR web-site. NO useful information yet a lot of mayonnaise through molecule naming. This misses in depth pages on what they RELAY DO.

Would be interested to see WHAT EXACTLY Dr. Wolchok would support in that.