Thursday, May 25, 2017 8:28:48 AM
1.) In this study, we examined the effect of an intermittent biphasic (square wave / ENDV Patented) on our artificial heart muscle (AHM).
2.) We demonstrate improved consistency between samples for twitch force and contraction rate, and higher normalized twitch force amplitudes for electrically stimulated AHMs.
3.) Improvements in electrophysiology within the AHM were noted by higher conduction velocities and lower latency in electrical response for electrically stimulated AHMs.
4.) Genes expressing key electrophysiologic and structural markers peaked at days 6 and 8 of culture, ( only a few days after the initiation of ES. ) *****NOTE this is MUCH LESS TIME / Normally takes WEEKS!
*****5.)These results may be used for optimization strategies to establish protocols for producing AHMs ( capable of replacing damaged heart tissue in either a contractile or electrophysiologic capacity. )
*****6.) Optimized AHMs can lead to alternative treatments to heart failure and alleviate the limited donor supply crisis.=BIG MONEY
http://insights.ovid.com/pubmed?pmid=28459744
TO BE OFFICIALLY PUBLISHED IN JUNE:
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