Endonovo Therapeutics Inc (ENDV)

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May 19, 2017
Weekly Recap From the Expedition Lead Scientist
https://www.nasa.gov/mission_pages/station/research/news/wklysumm_week_of_15may17.html


Investigation studies effect of new drug on osteoporosis

When people and animals spend extended periods of time in space, they experience bone density loss, or osteoporosis. In-flight countermeasures, such as exercise, prevent it from getting worse, but there isn’t a therapy on Earth or in space that can restore bone that is already lost. The Systemic Therapy of NELL-1 for osteoporosis (Rodent Research-5) investigation tests a new drug that can both rebuild bone and block further bone loss, improving health for crew members.

Exposure to microgravity creates a rapid change in bone health, similar to what happens in certain bone-wasting diseases, during extended bed rest and during the normal aging process. The results from this ISS National Laboratory-sponsored investigation build on previous research also supported by the National Institutes for Health and could lead to new drugs for treating bone density loss in millions of people on Earth.

Research seeks to understand the heart of the matter

Exposure to reduced gravity environments can result in cardiovascular changes such as fluid shifts, changes in total blood volume, heartbeat and heart rhythm irregularities, and diminished aerobic capacity. The Fruit Fly Lab-02 study will use the fruit fly (Drosophila melanogaster) to better understand the underlying mechanisms responsible for the adverse effects of prolonged exposure to microgravity on the heart. Flies are smaller, with a well-known genetic make-up, and very rapid aging that make them good models for studying heart function. This experiment will help to develop a microgravity heart model in the fruit fly. Such a model could significantly advance the study of spaceflight effects on the cardiovascular system and facilitate the development of countermeasures to prevent the adverse effects of space travel on astronauts.