Insmed Inc (INSM)

[Christiaan F]

New research confirms treatment Diabetes:

Insulin-like growth factor I: a predictor of long-term glucose abnormalities in patients with acute myocardial infarction.
Wallander (M). Brismar (K). Ohrvik (J). Rydén (L). Norhammar (A).

Journal: Diabetologia 49(10) 2006 8 29

AIMS/HYPOTHESIS: Low levels of IGF-I are associated with increased risk of cardiovascular disease and type 2 diabetes. The aim of this study was to investigate the IGF-I system in patients with acute myocardial infarction (AMI) without previously known diabetes. MATERIALS AND METHODS: One hundred and sixty-eight AMI patients were classified before hospital discharge by means of an OGTT as having NGT, IGT or newly detected type 2 diabetes. Age- and sex-matched subjects from the background population (n=185) served as the control group. The associations between fasting levels of IGF-I and IGF binding proteins 1 and 3 (IGFBP-1, IGFBP-3) and glucose metabolism during a follow-up period of 12 months were studied. RESULTS: At hospital discharge, age-adjusted IGF-I (IGF-I SD) was significantly lower in patients with abnormal glucose tolerance (AGT=IGT or type 2 diabetes) compared with patients with NGT (p=0.014) and control subjects.
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