Synaptogenix Inc (SNPX)

[MrGuru]

This can explain why the 40 ug/M2 dosis results were inferior (the Downregulation mechanism was known before). Some people has cited the lack of higher dose reports as something "fishy". Is highly possible that lower dosis can produce even better results. Question is what would be the best application frequency.

"Downregulation is particularly significant at higher doses of bryostatin, e.g., >30 µg/m2/week. Downregulation may potentially complicate the therapeutic use of bryostatin 1 because it could produce effects that are different or even opposite from activation. Therefore, it is important to optimize clinical trial protocols to maximize the lower dose biochemical effect of PKC? activation."