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Re: mjw007 post# 913

Friday, 05/12/2017 4:07:56 PM

Friday, May 12, 2017 4:07:56 PM

Post# of 2099
It's still early but I thought this was a good interpretation of the results.
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An important observation from our pre-clinical data in the LLC model was that the combination of VB-111 at a dose of 10^9 viral particles (VPs)/mouse, which is equivalent to the human therapeutic dose, with a PD-L1 blocker, yielded a tumor burden reduction similar to treatment with 10^11 VPs/mouse, a 100-fold higher dose ... Therefore, a combination with a checkpoint inhibitor may achieve much better anti-tumor activity than VB-111 alone
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