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THE CAPITAL GAINS CLUB TOP PICK May 12th

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petunia1   Friday, 05/12/17 03:54:14 PM
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THE CAPITAL GAINS CLUB TOP PICK May 12th 2017

OUR TOP BIOTECH PICK: 3D SIGNATURES INC.

(TSXV:DXD and OTCQB: TDSGF)

Predicting the course of diseases and personalizing treatment for the individual patient
 
“If successful, this could represent a first-in-class blood test which would specifically identify clinically significant prostate cancer. Such a tool does not currently exist for prostate cancer patients” said Dr. Laurence Klotz, the Chairman of the Canadian Urology Research Consortium
 
Executive Summary: 3D Signatures is a personalized medicine company with a proprietary software platform based on the three-dimensional (3D) analysis of chromosomal signatures. The technology is well developed and supported by 22 clinical studies on over 2,000 patients on 13 different cancers and Alzheimer’s disease. Depending on the desired application, this platform technology can measure the stage of disease, rate of progression of disease, drug efficacy, and drug toxicity. The technology is designed to predict the course of disease and to personalize treatment for the individual patient.

Dr. Sabine Mai, is the founder and largest shareholder of the company and is an internationally known researcher who has more than one hundred publications related to research on Genomics and Genomic Instability. Most recently she has contributed to a library of patents related to her work on 3D Genomic Analysis. She is the recipient of several academic awards including the Braidwood Jackson Memorial Award; the Dr. Saul Highman Memorial Award; the Rh Award (Basic Science); the J&J Cognition Challenge (2013). She was recognized in 2015 as one of the Top 100: Canada’s Most Powerful Women.

Dr. Mai has been instrumental in the development of innovative 3D analysis of genomic instability, which will help in diagnosing more specifically and earlier several forms of cancer. This will allow physicians to personalize treatment and improve the quality of outcomes. During the course of more than twenty years of research she has contributed to a portfolio of patents protecting her discoveries. Her vision is to use her discoveries for the benefit of patients everywhere.

Jonathan Goodman, the CEO of Knight Therapeutics Inc. (over $1 billion market capitalization biotech company) is a key advisor to 3D Signatures. In addition, Knight Therapeutics invested in 3D Signatures and has signed definitive licensing and distribution agreements with the company.

One of the main reasons we like 3D Signatures and the stock is because of its proprietary technology that analyzes a specific part of an individual’s unique DNA (their telomeres) to determine how a disease will progress and if a patient will respond to treatment. This information enables clinicians to measure the appropriateness and effectiveness of different treatments for specific patients.

3D Signature’s technology has over 20 years of research and over $25 million in non-dilutive research & development funding.

No wonder the board and management own approximately 35% of the company!

This is not an early stage biotech company with an undeveloped drug or technology platform – this is a company with an innovative technology and a dedicated team that only makes millions of dollars and saves countless lives if they continue to develop the technology with a view to selling the company to a much larger biotechnology company. We believe the company is poised for exponential gains and we have never sold a share. As the company progresses through various trials and continues to enter into partnerships with other companies, we believe the stock will perform well and the company will attract analysts and large fund managers.  

The best way to make large sums of money in a stock is being positioned in a take-over target and that is what we believe 3D Signatures is.
 
Why a big Pharmaceutical company would acquire 3D Signatures

Hodgkin lymphoma
There are approximately 10,000 new cases of Hodgkin lymphoma and an estimated 1,500 deaths in the United States and Canada each year. Physicians cannot today predict which patients will respond to standard chemotherapy and enter long-term remission or not respond and relapse, requiring alternative but more aggressive forms of therapy. THERE IS CURRENTLY NO TEST TO PREDICT WHETHER PATIENTS WILL RESPOND TO STANDARD CHEMOTHERAPY OR NOT.

Prostate cancer
Every year, there are over three million existing and new cases of prostate cancer in the United States and Canada. A large proportion of these patients are needlessly overtreated and/or subjected to surgery -- costing the health care payers billions of dollars annually and inflicting unnecessary treatment and complications on patients. There is a significant unmet need, at every stage of the disease, for accurate and minimally invasive risk assessment tools to allow clinicians to make better treatment decisions. 3D Signatures wants to arm physicians with the tools necessary to confidently personalize treatment decisions for each individual prostate cancer patient. NO SUCH TESTS CURRENTLY EXIST.

Drug development
Based on published work by Dr. Mai and her collaborators regarding real-time ex vivo feedback on several new therapeutic candidates and inbound interest from a number of major pharmaceutical companies, 3D Signatures is activating a dedicated strategy to engage industry in discussions around partnership opportunities. 3D Signatures' technology has the potential to identify lead therapeutic candidates through drug screening, select specific patients for clinical trials, monitor patients during clinical trials and ultimately work with pharmaceutical companies on the approval of companion diagnostics for precision medicine. There is significant potential value to be realized by pharmaceuticals companies in the form of efficient identification of new drugs, targeted clinical trials, objective real-time feedback during clinical trials and expedited regulatory approval by way of companion diagnostics.
 
3D Signature’s plan over the course of 2017:
Validation and preliminary approval of its lead prognostic test for Hodgkin lymphoma;
Initiation of a major clinical trial for blood-based monitoring tests for prostate cancer;
Strategic engagement with pharmaceutical companies for development of companion diagnostics; and
Securing the right people and partners to elevate its business.
 
The Team:
Dr. Sabine Mai: Founder and Major Shareholder
Professor of Physiology and Pathophysiology, Biochemistry and Medical Genetics, Human Anatomy and Cell Science, University of Manitoba.
Director of The Genomic Centre for Cancer Research and Diagnosis (GCCRD) at University of Manitoba.
She was recognized in 2015 as one of the Top 100: Canada’s Most Powerful Women.
Jason Flowerday: CEO and Director
over a decade of business development and marketing work for two of the world’s largest pharmaceutical companies, Germany’s Bayer AG and US-based Johnson and Johnson.
Jonathan Goodman: Business Advisor
CEO of Knight Therapeutics (investor and partner with 3D Signatures)
The co-founder, President and CEO of Paladin Labs Inc. which was acquired by Endo for $3.2 billion. Under his leadership, $1.50 invested in Paladin at its founding was worth $142 nineteen years later.
 
The Potential: 3D Signatures is in discussions with multiple pharmaceutical companies, with candidate compounds in all phases of clinical trials, about potentially incorporating 3D Signature’s three-dimensional telomere analysis and proprietary software into their trials. The company can offer these organizations significant insight into the efficacy of their compounds and possibly provide information on dose dependent response, as well as toxicity related to each compound.
 
On December 7, 2016, 3D Signatures presented the preliminary results of an important collaborative initiative between the company and the Institut Universitaire de Ariologie et de Pneumologie De Quebec (“IUCPQ”) exploring the possibility of identifying a biological marker to distinguish between two deadly forms of lung cancer, multiple synchronous lung adenocarcinoma (“AC”) and metastatic lung AC, which is a significant unmet clinical need in the management of patients with multiple lung lesions. In every blinded patient sample the company analyzed, 3D Signature’s technology was able to distinguish between the two respective types of deadly lung cancer. The acquisition of 3D telomere images and analysis was performed in the company's reference lab using the company’s proprietary software platform, TeloView™. A poster was presented at the International Association for the Study of Lung Cancer (“IASLC”) 17th World Conference on Lung Cancer (“WCLC”) which took place in Vienna, Austria from December 4 to December 7, 2016.

3D Signature’s technology has over 20 years of research and over $25 million in non-dilutive research & development funding.

No wonder the board and management own approximately 35% of the company!

The upside potential is huge and there are many catalysts to shoot the stock a lot higher. The company has laid out its business plan and if they continue to execute on time and on budget then we see our exit through a takeover. We hold shares in this company. Will you?
 
Enjoy the Gains,
Capital Gains Club
C. Sargent, Managing Editor



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