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Saturday, May 06, 2017 4:34:28 PM
"At the present time the random code has not been broken, however of the 18 treated patients 3-4 patients have receive placebo and 14-15 patients have received active drug. The average spontaneous remission rate in this population is approximately 25%, and 4-5 patients spontaneously remit assuming the experimental agent was ineffective, but in the 18 patients treated to date, irrespective of treatment, 14 have remitted. Thus, a therapeutic effect of the agent on the precancerous condition of CIN is being observed."
So hypothetically (say 4 placebo and 14 active drug) interpret that 14 have remitted, possibly subtract 2 placebo (assuming 50% natural remission from placebo) from 14 equals 12. From the remaining 12 remitters hypothetically say 33% natural remission from this group, so subtract 4 =8 remissions possibly due to our treatment.
So maybe 8 remissions due to our treatment out of the total of 14 possibly? This is assuming that all numbers are from the mid dose leg? Tough to tell for sure on this as sample size is small.
But I personally feel that there are enough results between this and the low dose to hypothetically argue that the CIN study was not a failure; and possibly worth pursing in the future, especially with increased dosage levels. If I remember right from TM; the potential CIN market is huge. I also possibly remember reading that the LEEP procedure can possibly prevent future ability for pregnancy.
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