Synaptogenix Inc (SNPX)

[SF Wolf]

 Momentous Alzheimer’s Disease Readouts

Sunday, April 23, 2017 at 10:01AM | by Michael Bigger | Comments Off

Neurotrope (NTRP) will release its Bryostatin Phase 2b top line data this week (company’s guidance). The primary efficacy endpoint is based on Severe Impairment Battery Scale (SIB). Entry criteria was based on the MMSE score. Secondary efficacy endpoints were based on – Activities of Daily Living (ADL), Neuropsychiatric Inventory (NPI), and Mini-Mental State Exam (MMSE).

Considering 70% of all phase two drug trials fail, and even more so with Alzheimer’s Disease (AD) indications, this will be a cage fighting, raw, win or lose, zero or hero event.

We are long NTRP and we wrote about our thesis right here. We are comfortable with our position given our utility curve, our assessment of the situation, its risk and reward potential.

We have the utmost respect for investors going into the event with a short or long position based on their assessment. This is not easy; it shows conviction with a position under imperfect information.

Given the history of AD trials results, it is understandable that many label this situation as a failure from the get go. To be clear, we are handicapping the probability of success and its associated payoff much differently.

http://biggercapital.squarespace.com/biggercapital-investment/2017/4/23/momentous-alzheimers-disease-readouts.html