AccesswireApril 18, 2017
TORONTO, ON / ACCESSWIRE / April 18, 2017 / Theralase Technologies Inc. ("Theralase®" or the "Company") (TSX-V: TLT) (OTC PINK: TLTFF), a leading biotech company focused on the commercialization of medical devices to eliminate pain and the development of Photo Dynamic Compounds ("PDCs") to destroy cancer, announced today that the second patient was treated on April 12, 2017 for Non-Muscle Invasive Bladder ("NMIBC") cancer using its novel Photo Dynamic Therapy ("PDT") technology.
The PDT treatment procedure involves the instillation of a water based solution of Theralase's lead anti-cancer PDC, TLD-1433, through the urethra into the bladder of the patient, to allow localization of the PDC to the NMIBC. The bladder is then drained of the solution, flushed with sterile water to remove excess solution and refilled with sterile water via a cystoscope. At this point, a fibre optic assembly, with the ability to both emit and detect laser light, is inserted through the cystoscope to activate the PDC.
The Phase Ib NMIBC clinical study ("Study") will be used to evaluate TLD-1433 for the primary endpoints of safety and tolerability, a secondary endpoint of pharmacokinetics (movement and exit of drug within tissue), and an exploratory endpoint of efficacy.
The Study has been designed to treat 3 patients at a lower dose of the PDC and to monitor the patients for 30 days, according to the endpoint criteria above. If successful, then an additional 6 patients will be enrolled into the Study to be treated at a higher dose of the PDC and monitored for 180 days, according to the endpoint criteria.
The next patient in the Study has been enrolled and is currently scheduled for treatment.
Roger Dumoulin-White, President and CEO of Theralase, stated that, "Theralase has now completed PDT treatment of 2 patients and looks forward to successfully treating the next patient and reporting out on the status of the first three patients in the Study in 2Q2017."
