Synaptogenix Inc (SNPX)

[InTheTrenches]

Several points about PKC epsilon and Bryostatin, based on the literature and Dr. Alkon's conference presentations:

- Normal PKC epsilon levels are necessary for synaptogenesis, natural clearance of Beta-Amyloid and tau tangles, and for neoronal protection.

- Most cases of Alzheimer's are characterized by abnormally low PKC epsilon, which leads to a loss of synapses, buildup of Beta-Amyloid and tau tangles, and increased death of neurons.

- The goal of using Bryostatin is to artificially restore normal levels of PKC epsilon.

- Those who have normal levels of PKC epsilon, don't experience "unregulated synaptogenesis" or seizures or "behavioral/psyche" issues or "long-term health problems like steroids".

- So, if normal levels of PKC epsilon doesn't cause health issues, we should turn our attention to the drug Bryostatin (used to elevate PKC epsilon to normal levels) to see if it has any nasty side-effects. Bryostatin has been given to >1500 patients, long-term, at high doses. So far, the mild side-effects at the doses in the phase 2b trial of Bryostatin has required the use of tylenol. Maybe we need to investigate tylenol to see if it has any nasty side-effects, because so far, Bryostatin is safe.

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Hypothetical concerns about "unregulated synaptogenesis causing seizures or behavioral/psyche issues" or concerns about side-effects similar to anabolic steroid use are non-sequitors.